Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

ConclusionsTaken together, our results strongly implicate epigenetic deregulation of LADs as an important and previously unrecognized feature of HGPS, which contributes to disease-specific gene expression. Therefore, they not only add a new layer to the study of epigenetic changes in the progeroid syndrome, but also advance our understanding of the disease ’s pathology at the cellular level.

http://link.springer.com/10.1186/s13073-020-00749-y

Source: Genome Medicine - May 24, 2020 Category: Genetics & Stem Cells Source Type: research