What ’s the Deal with Hydroxychloroquine and Diabetes?

Does the Trump-hyped drug hydroxychloroquine have the potential to treat diabetes?
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs

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We report a 30-year-old female patient with diabetes who has acromegaloid features, prominent umbilicus, prominent muscles, prominent subcutaneous veins, and gross hepatomegaly. Near-total loss of subcutaneous fat was confirmed by whole-body magnetic resonance imaging and laboratory data revealed significant hypertriglyceridemia, uncontrolled diabetes mellitus, and heavy proteinuria with stage IIIa chronic kidney disease. Her blood film revealed thrombocytosis that on further evaluation by bone marrow biopsy was confirmed to be a myeloproliferative neoplasm (MPN); essential thrombocytosis (ET). She also had skin lesions th...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
We report a case of TBIRS in an Arab patient with mixed connective tissue disease (MCTD). Investigations revealed a clinical condition marked by positive anti-insulin receptor and ribonucleoprotein antibodies. The patient presented with severe hyperglycemia, weight loss, arthralgia, and acanthosis nigricans. He was managed successfully with an intensive pulsed combination regimen of cyclophosphamide and plasmapheresis augmented with high doses of prednisolone, which normalized his blood sugar levels without insulin therapy. MCTD was controlled by hydroxychloroquine. During the course of his treatment, the patient developed...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Publication date: Available online 11 July 2020Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Jinxia Meng, Zhouya Bai, Wenqi Huang, Ying Liu, Peilin Wang, Shaoping Nie, Xiaojun Huang
Source: Bioactive Carbohydrates and Dietary Fibre - Category: Food Science Source Type: research
AbstractGlycated hemoglobin (HbA1c) is an important indicator of glycemic control in patients with diabetes. High-performance liquid chromatography (HPLC) is the most commonly used method for measuring HbA1c levels; as HPLC measures all hemoglobin types, the values can be influenced by hemoglobin variants. Moreover, as HPLC-HbA1c levels are low in some diseases, including hemolytic anemia, it may be difficult to differentiate hemoglobin variants from these diseases based on HPLC-HbA1c levels alone. Similar HbA1c values using both HPLC and immunoassays (IAs) are noted for these diseases, while discrepancies are noted in the...
Source: Diabetology International - Category: Endocrinology Source Type: research
ConclusionsThe DAPT Score might be useful to for identifying with ACI who are suitable to receive aspirin combined with clopidogrel. Future large-scale, multi-center prospective studies are necessary.
Source: Neurological Sciences - Category: Neurology Source Type: research
AbstractThe mechanism underlying the pathogenesis of diabetes is complex and poorly understood. Recent investigations have revealed thatinsulin gene mutations can lead to the development of specific subtypes of diabetes. This systematic review aimed to explore the associations ofinsulin gene mutations and insulin translocation defects with diabetes. This review was generated using articles from PsycINFO, PubMed, Web of Science, and CINAHL. Search terms and phrases such as “diabetes,” “mutations,” “insulin,” “preproinsulin,” “INS gene, ” “role,” “...
Source: Endocrine - Category: Endocrinology Source Type: research
Barney Calman, pictured with former Olympic triple jumper Michelle Robinson ahead of testing the theory that carbohydrate in food broken down into single sugar molecules have the same impact on blood sugar levels.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 11 July 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Federico Boscari, Mario Luca Morieri, Anna Maria Letizia Amato, Valeria Vallone, Ambra Uliana, Anna Baritussio, Nicola Vitturi, Elisa Cipponeri, Francesco Cavallin, Angelo Avogaro, Gian Paolo Fadini, Daniela Bruttomesso
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: October 2020Source: Journal of Functional Foods, Volume 73Author(s): Christopher M. McLaughlin, Shaun J. Sharkey, Pádraigín Harnedy-Rothwell, Vadivel Parthsarathy, Philip J. Allsopp, Emeir M. McSorley, Richard J. FitzGerald, Finbarr P.M. O'Harte
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 10 July 2020Source: The Lancet Diabetes &EndocrinologyAuthor(s): The Lancet Diabetes &Endocrinology
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
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