Dosage adjustment in obese children, even for common drugs, is largely unclear and a treat-to-effect approach may work best

AbstractObesity in children, often accompanied by comorbidities, is increasingly common. For many frequently used paediatric drugs, information on dosage adjustment in obese children is lacking or absent. Scalars, such as total body weight, are not always helpful as obese children may weigh more than adults, but differ with regard to aspects of their anatomy and physiology, especially hepatic function. Further pharmacokinetic studies in obese children are urgently needed and, in the interim, close monitoring for therapeutic effect and toxicity is recommended.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research