Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin

Mithramycin is an anti-tumor compound of the aureolic acid family produced by Streptomyces argillaceus. Its biosynthesis gene cluster has been cloned and characterized, and several new analogs with improved pharm...

Source: Microbial Cell Factories - May 24, 2020 Category: Microbiology Authors: Daniel Zabala, Lijiang Song, Yousef Dashti, Gregory L. Challis, Jos é A. Salas and Carmen Méndez Tags: Research Source Type: research