GSE141027 Reduced lipolysis is a common lipid accumulation mechanism for different subtypes of lipomas

Contributors : Diana Le Duc ; Chen-Ching Lin ; Yulia Popova ; Zuqin Yang ; Velluva Akhil ; Mehmet V Cakir ; Sonja Grunewald ; Jan-Christoph Simon ; Andreas Dietz ; Dirk Dannenberger ; J ürgen Schiller ; Matthias Blüher ; Ulrike Rolle-Kampczyk ; Martin von Bergen ; Janet Kelso ; Torsten SchönebergSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used RNA-seq to inquire gene expression profiles of lipomas with HMGA2-fusions and without gene fusions. We demonstrate that HMGA2-fusions lipomas are a specific subtype and that the common shared lipid accumulation mechanism is a reduction in lipolysis, with most gene-dysregulations leading to a reduced cAMP in the adipocyte.

Source: GEO: Gene Expression Omnibus - May 25, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research