Epigenetics in Health and Disease.

Epigenetics in Health and Disease. Adv Exp Med Biol. 2020;1253:3-55 Authors: Zhang L, Lu Q, Chang C Abstract Epigenetic mechanisms, which include DNA methylation, histone modification, and microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA sequence. Disruption of gene expression patterns which are governed by epigenetics can result in autoimmune diseases, cancers, and various other maladies. Mechanisms of epigenetics include DNA methylation (and demethylation), histone modifications, and non-coding RNAs such as microRNAs. Compared to numerous studies that have focused on the field of genetics, research on epigenetics is fairly recent. In contrast to genetic changes, which are difficult to reverse, epigenetic aberrations can be pharmaceutically reversible. The emerging tools of epigenetics can be used as preventive, diagnostic, and therapeutic markers. With the development of drugs that target the specific epigenetic mechanisms involved in the regulation of gene expression, development and utilization of epigenetic tools are an appropriate and effective approach that can be clinically applied to the treatment of various diseases. PMID: 32445090 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: Alteration of signal transduction by a drug is the goal of chemogenomics, a new branch formed by combination of chemistry and genomics. The proliferation, angiogenesis and apoptosis of cancer cells are regulated by cellular signaling of transcription factors, protein kinases, transmembrane receptors, extracellular ligands and some external factors like oncogenic mutations, ubiquitin-proteasome pathway with epigenetic changes. Traditional anticancer drugs either alter DNA synthesis or control cell division while new drugs retard tumor growth or induce apoptosis. The deterioration of dopaminergic neurons in subst...
Source: Current Signal Transduction Therapy - Category: Molecular Biology Source Type: research
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Source: Current Chemical Biology - Category: Biochemistry Source Type: research
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Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research
Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease most commonly involving skin, joints, and kidneys. Usually, it presents in women in puberty or early adulthood. This monograph provides an overview of the role of an obstetrician-gynecologist (ob-gyn) in the treatment of SLE patients. An ob-gyn is uniquely placed in the health care continuum throughout the life cycle of a woman. Notably, an ob-gyn often is the first physician to notice SLE-related rash, swollen joints, cytopenias, or proteinuria in a patient and is the first to provide initial management. Obstetrician-gynecologists must b...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
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Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Arthritis Autoimmune diseases Health Inflammation Lung disease Source Type: blogs
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Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research
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Source: Clinics - Category: General Medicine Source Type: research
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