IJERPH, Vol. 17, Pages 3713: Caries Increment and Salivary Microbiome during University Life: A Prospective Cohort Study

IJERPH, Vol. 17, Pages 3713: Caries Increment and Salivary Microbiome during University Life: A Prospective Cohort Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17103713 Authors: Yoko Uchida-Fukuhara Daisuke Ekuni Md Monirul Islam Kota Kataoka Ayano Taniguchi-Tabata Daiki Fukuhara Naoki Toyama Terumasa Kobayashi Kohei Fujimori Nanami Sawada Yoshiaki Iwasaki Manabu Morita The purpose of this 3-year prospective cohort study was to explore the relationship between an increase in dental caries and oral microbiome among Japanese university students. We analyzed 487 students who volunteered to receive oral examinations and answer baseline (2013) and follow-up (2016) questionnaires. Of these students, salivary samples were randomly collected from 55 students at follow-up and analyzed using next-generation sequencing. Students were divided into two groups: increased group (Δdecayed, missing, and filled teeth (ΔDMFT) score increased during the 3-year period) and non-increased group (ΔDMFT did not increase). Thirteen phyla, 21 classes, 32 orders, 48 families, 72 genera, and 156 species were identified. Microbial diversity in the increased group (n = 14) was similar to that in the non-increased group (n = 41). Relative abundances of the family Prevotellaceae (p = 0.007) and genera Alloprevotella (p = 0.007) and Dialister (p = 0.039) were enriched in the increased group co...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research