The essential function of IL-33 in metabolic regulation.

The essential function of IL-33 in metabolic regulation.
Acta Biochim Biophys Sin (Shanghai). 2020 May 22;:
Authors: Li W, Li Y, Jin J
Abstract
Interleukin-33 (IL-33) is produced by various types of cells under physical or pathological conditions. As a multifunctional partner in health and disease, current evidence reveals that IL-33 also participates in several metabolic processes. IL-33 has been proven to contribute to regulating the activity of ST2+ group 2 innate lymphoid cells and regulatory T cells in adipose, which leads to the shift of insulin sensitivity and glucose clearance in glucose metabolism, thermogenesis, and adipocyte beiging in adipose metabolism. In this review, we briefly summarize the biological characteristics of Il-33 and discuss its regulatory function in glucose and adipose metabolism. By clarifying the underlying mechanism of IL-33, we highlight the crosstalk between immune response and metabolic processes mediated by IL-33.
PMID: 32445465 [PubMed - as supplied by publisher]

Source: Acta Biochimica et Biophysica Sinica - May 21, 2020 Category: Biochemistry Authors: Li W, Li Y, Jin J Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research