TCAs and NaHCO3

In Sketchy they say Sodium Bicarbonate is used to treat TCA overdose. One of the reasons they say is because it increases serum pH which favors the non-ionized form of the drug. Why is this? I thought increase serum pH> less H+. Then to compensate for this decrease in H+, wouldn't TCA ionize more to replace to lost H+ ions?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Medical Students - MD Source Type: forums

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CONCLUSIONS: ILE therapy comprises a recognized approach in clinical toxicology. Due to the lack of randomized clinical trials, recommendations on administration are based on animal studies and published cases. Thus, the constantly increased knowledge about ILE therapy supports the need for a detailed appraisal. PMID: 32633409 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
A secret U.S. safe haven where drug users can give themselves heroin and other drugs has observed more than 10,500 injections over five years with no fatal overdoses
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Trevor BurrusThe first major federal drug law, the Harrison Narcotics Act, went into effect in 1915. As the federal drug war moves into its second century, we are still faced with an unprecedented opioid crisis that isgetting worse during the current pandemic. Yet while other countries such asPortugal andSwitzerland are approaching the problem with new, more humane ideas, the federal government is stuck in the prohibitionist mindset of the past, which not only doesn ’t work but makes the problem worse. Safehouse is a nonprofit public ‐​health organization that seeks to mitigate the harms of the opioid c...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Authors: Evans ME, Person M, Reilley B, Leston J, Haverkate R, McCollum JT, Apostolou A, Bohm MK, Van Handel M, Bixler D, Mitsch AJ, Haberling DL, Hatcher SM, Weiser T, Elmore K, Teshale EH, Weidle PJ, Peters PJ, Buchacz K Abstract OBJECTIVES: Hepatitis C virus (HCV) and HIV transmission in the United States may increase as a result of increasing rates of opioid use disorder (OUD) and associated injection drug use (IDU). Epidemiologic trends among American Indian/Alaska Native (AI/AN) persons are not well known. METHODS: We analyzed 2010-2014 Indian Health Service data on health care encounters to assess region...
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
Aug 27, 2020. . Sponsored by Maryland Rural Opioid Technical Assistance, University of Maryland Extension
Source: Rural events via the Rural Assistance Center - Category: Rural Health Source Type: events
Conclusions: OUD is more prevalent among certain sociodemographic groups in the US. Targeted interventions focusing on young, White, unmarried, male, and uninsured/Medicaid/Medicare populations should be implemented to reduce the OUD. PMID: 32633664 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment. Although generally safe they are potentially lethal in overdose.In-vitro data suggest that high concentrations and thus high doses are needed for COVID-19 infections, but as yet there is no convincing evidence of clinical efficacy. Bayesian regression models were fitted to survival outcomes and electrocardiograph QRS durations from 302 prospectively studied French patients who had taken intentional chloroquine overdoses, of whom 33 died (11%), and 16 healthy volunteers who took 62...
Source: eLife - Category: Biomedical Science Tags: Human Biology and Medicine Source Type: research
Clinical advancement of the bioartificial liver is hampered by the lack of expandable human hepatocytes and appropriate bioreactors and carriers to encourage hepatic cells to function during extracorporeal circulation. We have recently developed an efficient approach for derivation of expandable liver progenitor-like cells from human primary hepatocytes (HepLPCs). Here, we generated immortalized and functionally enhanced HepLPCs by introducing FOXA3, a hepatocyte nuclear factor that enables potentially complete hepatic function. When cultured on macroporous carriers in an air-liquid interactive bioartificial liver (Ali-BAL...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
A recent report provides evidence that the coronavirus pandemic is sparking a severe medical crisis among illicit drug users. VCU Medical Center in Richmond is seeing 50 to 60 overdoses per month.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
New data from the First Nations Health Authority shows that overdose deaths among First Nations people have surged dramatically and disproportionately during the COVID-19 pandemic in B.C.
Source: CBC | Health - Category: Consumer Health News Tags: News/Indigenous Source Type: news
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