Peptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation

Very little is known about how peptides activate signaling pathways that play a crucial role in diseases such as cancer. Specifically, we reported one conserved peptide encoded by LINC00998, SMIM30. This peptide promoted the tumorigenesis of HCC by modulating cell proliferation and migration. Of note, it bound the non-receptor tyrosine kinases, SRC/YES1, to drive their membrane anchoring and phosphorylation, activating the downstream MAPK signaling pathway. Our work not only unravels a new mechanism of HCC tumorigenesis promoted by peptides, but also demonstrates how the peptide works in activating the signaling pathway.

Source: Journal of Hepatology - May 23, 2020 Category: Gastroenterology Authors: Yanan Pang, Zhiyong Liu, Huan Han, Beilei Wang, Wei Li, Chuanbin Mao, Shanrong Liu Source Type: research