The effect of caraway ( Carum carvi L.) on the blood antioxidant enzymes and lipid peroxidation in streptozotocin-induced diabetic rats

Abstract Different studies have shown that oxidative stress has an important role in both types of diabetes mellitus. The aim of this study was to evaluate the effect of different doses of Carum carvi oil on antioxidant enzymes of streptozotocin-induced diabetic rats. Fifty-six Wistar male rats weighing between 250 ± 50 g were divided into seven equal groups. Diabetes was induced in the experimental rats with streptozotocin (60 mg kg−1 body weight). Rats in group I served as the normal control animals; group II served as the caraway control, whereas group III served as the diabetic control and group IV was the diabetic control which received sunflower oil. Groups V to VII were the test groups receiving various oral doses of caraway oil (5, 10, and 20 mg kg−1 body weight, respectively). The experiment lasted for a period of 30 days, and the following antioxidant enzymes were assayed: SOD, GSH-Px, CAT, and MDA. The results showed that rats receiving Carum carvi oil gained significantly more weight and had a lower level of blood glucose (P 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Conclusion A high prevalence of malnutrition and of other risk factors for cardiovascular disease were observed. Such factors included diabetes Mellitus, smoking and former smoker conditions and were associated with malnutrition. Inaddition, it was found that malnourished individuals were more likely to develop cardiovascular disease within 10 years.RESUMO Objetivo Verificar associa ção entre estado nutricional e fatores de riscos cardiovasculares tradicionais e não tradicionais em pacientes em hemodiálise. Métodos Estudo transversal com 132 pacientes maiores de 18 anos em hemodiál...
Source: Revista de Nutricao - Category: Nutrition Source Type: research
Individuals with established cardiovascular disease (CVD) and risk factors such as age, smoking, hypertension, and diabetes mellitus are at an increased risk of recurrent cardiovascular events and death. The i...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Research article Source Type: research
The objective of this longitudinal study was to evaluate NODM risk using the above two systems in Korean adults. METHODS: Among individuals enrolled in Kangbuk Samsung Health Study and Cohort Study who visited between 2011 and 2012 at baseline and 2014 at follow-up, 78,212 participants without baseline diabetes mellitus were followed up for a median of 27 months. Assessment of NODM incidence was made at the end of follow-up period. Cotinine-verified current smoking was having urinary cotinine ≥50 ng/mL. RESULTS: Percentages of self-reported and cotinine-verified current smokers were 25.9% and 23.5%, respectively...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Authors: Janssen LGM, van Dam AD, Hanssen MJW, Kooijman S, Nahon KJ, Reinders H, Jazet IM, van Marken Lichtenbelt WD, Rensen PCN, Appelman-Dijkstra NM, Boon MR Abstract BACKGROUND: South Asians generally have an unfavourable metabolic phenotype compared with white Caucasians, including central obesity and insulin resistance. The Wnt protein family interacts with insulin signaling, and impaired Wnt signaling is associated with adiposity and type 2 diabetes mellitus. We aimed to investigate Wnt signaling in relation to insulin signaling in South Asians compared with white Caucasians. METHODS: Ten Dutch South Asia...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
CONCLUSION: FGF21 prevents renal fibrosis via negative regulation of the TGF-β/Smad2/3-mediated EMT process by activation of the Akt/MDM2/p53 signaling pathway. PMID: 31701691 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Authors: Kim YG, Park DG, Moon SY, Jeon JY, Kim HJ, Kim DJ, Lee KW, Han SJ Abstract BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM. METHODS: We used the Korean National Health Insurance Service Senior cohort, which includes>10% of the entire senior population of South Korea. In total, 5,966 patients who had ever experienced at least one episode of hypoglycemia were matched with those who had not, using p...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
CONCLUSION: This study demonstrates that changes in physicians' behaviors, as a result of perceiving CV risks, improve QoL in some domains of life in DM patients. Physicians should recognize the importance of understanding CV risks and implement appropriate management. PMID: 31701689 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
CONCLUSION: Continuity of care for diabetes significantly reduced health complications and medical costs from patients with T2DM. PMID: 31701688 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
CONCLUSION: GLA treatment in patients with painful DPN was noninferior to ALA in terms of reducing pain intensity measured by the VAS over 12 weeks. PMID: 31701699 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Authors: Bae JH, Choi HJ, Cho KIK, Kim LK, Kwon JS, Cho YM Abstract BACKGROUND: To investigate the effects of a glucagon-like peptide-1 receptor agonist on functional brain activation in lean and obese individuals with type 2 diabetes mellitus (T2DM) in response to visual food cues. METHODS: In a randomized, single-blinded, crossover study, 15 lean and 14 obese individuals with T2DM were administered lixisenatide or normal saline subcutaneously with a 1-week washout period. We evaluated brain activation in response to pictures of high-calorie food, low-calorie food, and nonfood using functional magnetic resonan...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
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