Salivary oxytocin after oxytocin administration: Examining the moderating role of childhood trauma.

This study examined whether salivary oxytocin increased after oxytocin administration and whether trauma attenuated this effect. We conducted a randomized, double-blind, placebo-controlled, within-subjects study in 100 male adolescents living in residential youth care facilities. Participants self-administered intranasally 24 IU of oxytocin and placebo (one week later) and provided a saliva sample before and 15 min after administration. Salivary oxytocin increased significantly after oxytocin administration, but this effect might be inflated by exogenous oxytocin reaching the throat. Trauma did not moderate this effect. Our findings suggest that trauma did not attenuate the effect of oxytocin administration on salivary oxytocin, but more robust methodologies are recommended to draw more solid conclusions.
PMID: 32442673 [PubMed - as supplied by publisher]

Source: Biological Psychology - May 18, 2020 Category: Psychiatry & Psychology Authors: Fragkaki I, Glennon JC, Cima M Tags: Biol Psychol Source Type: research