Molecules, Vol. 25, Pages 2444: Anti-aggregation Effects of Phenolic Compounds on α-synuclein

Molecules, Vol. 25, Pages 2444: Anti-aggregation Effects of Phenolic Compounds on α-synuclein Molecules doi: 10.3390/molecules25102444 Authors: Kenjiro Ono Mayumi Tsuji Tritia R. Yamasaki Giulio M. Pasinetti The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson’s disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the onset and progression of clinical phenotypes. Thus, there is increasing interest in developing strategies that attenuate αS aggregation and propagation. Based on cumulative evidence that αS oligomers are neurotoxic and critical species in the pathogenesis of α-synucleinopathies, we and other groups reported that phenolic compounds inhibit αS aggregation including oligomerization, thereby ameliorating αS oligomer-induced cellular and synaptic toxicities. Heterogeneity in gut microbiota may influence the efficacy of dietary polyphenol metabolism. Our recent studies on the brain-penetrating polyphenolic acids 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-hydroxyphenylacetic acid (3-HPPA), which are derived from gut microbiota-based metabolism of dietary polyphenols, demonstrated an in vitro ability to inhibit αS oligomerization and mediate aggregated &...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research