ENT1 inhibition attenuates apoptosis by activation of cAMP/pCREB/Bcl2 pathway after MCAO in rats.

CONCLUSIONS: ENT1 inhibition prevented neuronal apoptosis and improves neurological deficits through cAMP/PKA/CREB/Bcl-2 signaling pathway after MCAO in rats. ENT1 might be an effective target in the treatment strategy for ischemic stroke.
PMID: 32445645 [PubMed - as supplied by publisher]

Source: Experimental Neurology - May 19, 2020 Category: Neurology Authors: Zhang D, Jin W, Liu H, Liang T, Peng Y, Zhang J, Zhang Y Tags: Exp Neurol Source Type: research