Anti-vascular endothelial growth factor antibody limits vascular leakage and decreases subretinal fibrosis in a cynomolgus monkey choroidal neovascularization model.
CONCLUSION: In our established cynomolgus monkey CNV model, bevacizumab prevented blood leakage but could not completely suppress fibrosis. SHRM in the OCT images reflected retinal fibrous tissue in a laser-induced CNV monkey model. Our model might be useful for elucidating the pathology and development therapy for neovascularization or fibrosis.
PMID: 32445455 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - Category: Neurology Authors: Inagaki S, Shimazawa M, Hamaguchi K, Otsu W, Araki T, Sasaki Y, Numata Y, Tsusaki H, Hara H Tags: Curr Neurovasc Res Source Type: research