Approaches To Optimizing Dantrolene Neuroprotection For The Treatment Of Alzheimer's Disease.

Approaches To Optimizing Dantrolene Neuroprotection For The Treatment Of Alzheimer's Disease. Curr Alzheimer Res. 2020 May 22;: Authors: Abou MB, Sun L, Wei H Abstract Alzheimer's Disease (AD), a neurodegenerative disorder with high incidence and mortality, is leading its way to the top of the list of the deadliest diseases [1], without an effective disease-modifying drug. Ca2+ dysregulation, specifically abnormal release of Ca2+ by over activated ryanodine receptor (RyR), has been increasingly considered as an alternative upstream mechanism in AD pathology. Consequently, dantrolene, a RyR antagonist and FDA approved drug to treat malignant hyperthermia and chronic muscle spasms, has been shown to ameliorate memory loss in AD transgenic mice. However, the inefficiency of dantrolene to pass the blood-brain barrier (BBB) and penetrate the CNS needs to be resolved, considering its dose-dependent neuroprotection in AD and other neurodegenerative diseases. In this minireview, we will discuss the current status of dantrolene neuroprotection in AD treatment and a strategy to maximize its beneficial effects, such as intranasal administration of dantrolene. PMID: 32442084 [PubMed - as supplied by publisher]
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research

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Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
CONCLUSION: In summary, the transdermal administration of Alzheimer's drugs is an interesting and promising topic, which should be further elaborated. PMID: 32552655 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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