Modulation of the drug resistance by Platonia insignis Mart. extract, ethyl acetate fraction and Morelloflavone/Volkensiflavone (biflavonoids) in Staphylococcus aureus strains overexpressing efflux pump genes.
CONCLUSION: P. inignisis a source of efflux pump inhibitors, including volkensiflavone and morelloflavone which were able to potentiate the Norfloxacin activity by NorA inhibition, being also able to inhibit QacA/B, TetK and MsrA. Volkensiflavone and morelloflavone could be used as adjuvant in the antibiotic therapy of multidrug resistant S. aureus strains overexpressing efflux pumps.
PMID: 32445452 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Ferreira E Silva AK, Dos Reis AC, Pinheiroc EEA, de Sousa JN, de Alcântara Oliveira FA, Moura AKS, de Souza Lima Neto J, das Graças Lopes Citó AM, de Siqueira-Júnior JP, Kaatz GW, Barreto HM Tags: Curr Drug Metab Source Type: research