Diagnostic Stewardship Approaches to Clostridioides difficile Infection in the Era of Two-Step Testing: a Shifting Landscape
AbstractPurpose of reviewTo discuss the current strategies and impact of diagnostic stewardship forClostridioides difficile infection.Recent findingsThe diagnosis ofC. difficile infection is challenging due to complex epidemiology and the limitations of a single assay that is adequate for diagnosis. Overdiagnosis with sensitive molecular assays is common due to the prevalence of colonization withC. difficile. To overcome these challenges, multiple diagnostic stewardship strategies have been successfully deployed to optimizeC. difficile testing.SummaryDiagnostic stewardship strategies should be implemented at every stage ofC. difficile testing in order to limit testing to patients with a high pre-test probability, minimize the limitations of stand-alone assays, and guide clinicians to appropriate management through clear result reporting and interpretation.
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research
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