Whole bowel irrigation in dapsone intoxication with persistent methemoglobinemia: A case report

We describe a case of a 17-year-old girl who was admitted 4  h after ingesting 5 g of dapsone. She presented methemoglobinemia (39%) and showed clinical signs of toxicity (cyanosis and altered mental status) despite mechanical ventilation. Multiple activated charcoal dosis and methylene blue infusions were performed. Notwithstanding initial improvement, a pattern of peaks and valleys was observed in serial methemoglobinemia measurements, with cyclic states of hypoxemia.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research