Outside-in hypothesis revisited: the role of microbial, epithelial and immune interactions
Our understanding of the origin of allergic diseases has increased in recent years, highlighting the importance of microbial dysbiosis and epithelial barrier dysfunction in affected tissues. Exploring the microbial-epithelial-immune crosstalk underlying the mechanisms of allergic diseases will allow the development of novel prevention and treatment strategies of allergic diseases.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Kazunari Sugita, Michael B. Soyka, Paulina Wawrzyniak, Arturo Rinaldi, Yasuaka Mitamura, M übeccel Akdis, Cezmi A. Akdis Tags: Review Source Type: research