Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection
The mitochondrial permeability transition, an established mechanism for heart diseases, is a long-standing mystery of mitochondrial biology and a prime drug target for cardioprotection. Several hypotheses about its molecular nature have been put forward over the years, and the prevailing view is that permeabilization of the inner mitochondrial membrane follows opening of a high-conductance channel, the permeability transition pore, which is also called mitochondrial megachannel or multiconductance channel.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Michela Carraro, Andrea Carrer, Andrea Urbani, Paolo Bernardi Source Type: research