The effects of exercise training on lipid metabolism and coronary heart disease.

The effects of exercise training on lipid metabolism and coronary heart disease. Am J Physiol Heart Circ Physiol. 2020 May 22;: Authors: Muscella A, Stefàno E, Marsigliante S Abstract Blood lipoproteins are formed by various amounts of cholesterol (C), triglycerides (TG), phospholipids and apolipoproteins (Apos). Apo A1 is the major structural protein of high-density lipoprotein (HDL), accounting for approximately 70% of HDL protein, and mediates many of the anti-atherogenic functions of HDL. Conversely, Apo B is the predominant low-density lipoprotein (LDL) Apo and is a reliable indicator of circulating LDL, associated with higher coronary heart disease (CHD) risk. Furthermore, the Apo B/Apo A1 ratio is used as a surrogate marker of the risk of CHD related to lipoproteins. Elevated or abnormal levels of lipids and/or lipoproteins in the blood is a significant CHD risk factor and several studies strongly support the idea that aerobic exercise decreases CHD risk partially lowering serum TG and LDL-cholesterol (LDL-C) levels and increasing HDL-C levels. Exercise also exerts an effect on HDL-C maturation and composition and on reverse C transport from peripheral cells to the liver, in order to favor its catabolism and excretion. This process prevents atherosclerosis and several studies showed that exercise training increases heart lipid metabolism and protects against cardiovascular disease. The purpose of this review is to assess the ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research