Biliary restoration using a combined endoscopic-percutaneous approach following “orphan duct syndrome” after pediatric liver transplantation

Publication date: Available online 23 May 2020Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Patrick B. Dennis, Elizabeth K. Nadeau, Jared White, Ricardo Yamada, D. Thor Johnson, B. Joseph Elmunzer, Vinayak Rohan, Nagraj Kasi, Satish N. Nadig
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research

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CONCLUSIONS: These results suggest that GL prevents inflammation in liver macrophages via inhibition of HMGB1. GL restrains inflammation and cell apoptosis by inhibiting HMGB1 via PI3K/mTOR signaling pathway in ALI. GL may become a novel drug for the therapy of ALI in the future. PMID: 32633407 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ConclusionsWe identified postmarketing cases of serious acute drug-induced liver injury causally associated with ulipristal used to treat uterine fibroids, some with outcomes of liver transplant and/or death. The presence of common structural features identified with certain selective progesterone receptor modulators in the treatment of chronic conditions may indicate a liability for idiosyncratic drug-induced liver injury.
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research
In recent years academic interest has grown in the study of the gut microbiome. Researchers are making inroads into understanding the considerable influence of these microbial populations over the progression of health and aging. The gut microbiome may be as influential as physical activity in these matters. The balance of microbial populations shifts unfavorably over time, for reasons that are yet to be fully mapped and understood. This leads to greater numbers of inflammatory microbes, or those that produce harmful byproducts, and fewer microbes that produce beneficial metabolites. Researchers have identified some of the...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Conditions:   Liver Transplant; Complications;   Liver Diseases;   Hemodynamic Instability Intervention:   Sponsor:   Institute of Liver and Biliary Sciences, India Not yet recruiting
Source: - Category: Research Source Type: clinical trials
CONCLUSIONS: Our study concluded that terlipressin and albumin combination was safe and effective in successfully stabilising cirrhosis patients with Hepatorenal Syndrome and bridging eligible patients to liver transplantation by restoring the liver and renal function with minimal adverse effects. PMID: 32634332 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
We report the long-term biochemical course and outcomes of patients with PSC treated with OV. METHODS: Patients were enrolled in 2 open-label clinical trials ( Identifier: NCT01802073 and NCT01322386) and offered OV at 50 mg/kg/day in 3 divided doses if weight
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
The original version of this article unfortunately contained a mistake in the author group section.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewPatients with congenital heart disease (CHD) are living longer due to advances in cardiovascular medicine. We sought to review the physiology and evaluation of these CHD patients who demonstrate the emerging need for combined heart and liver transplantation.Recent FindingsThe principal population affected by failing cardiohepatic physiology are those with single-ventricle physiology palliated to Fontan. Patients are evaluated by a multidisciplinary team including transplant cardiology and hepatology to determine the degree of liver damage and necessity of combined heart and liver transplantation. W...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
We have read with interest the recent publication by Verna et  al. describing a real-word experience of direct-acting antiviral (DAA) therapy and long-term hepatic function in patients with decompensated cirrhosis.1
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Publication date: Available online 30 June 2020Source: Hepatobiliary &Pancreatic Diseases InternationalAuthor(s): Yuichi Masuda, Kazuki Yoshizawa, Yasunari Ohno, Atsuyoshi Mita, Akira Shimizu, Yuji Soejima
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
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