Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-Analysis.

Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-Analysis. Chest. 2020 May 18;: Authors: Leitao Filho FS, Mattman A, Schellenberg R, Criner GJ, Woodruff P, Lazarus SC, Albert RK, Connett J, Han MK, Gay SE, Martinez FJ, Fuhlbrigge AL, Stoller JK, MacIntyre NR, Casaburi R, Diaz P, Panos RJ, Cooper JA, Bailey WC, LaFon DC, Sciurba FC, Kanner RE, Yusen RD, Au DH, Pike KC, Fan VS, Leung JM, Man SP, Aaron SD, Reed RM, Sin DD Abstract BACKGROUND: Hypogammaglobulinemia (serum immunoglobulin G (IgG) levels < 7.0 g/L) has been associated with increased risk of COPD exacerbations but has not yet been shown to predict hospitalizations. RESEARCH QUESTION: To determine the relationship between hypogammaglobulinemia and the risk of hospitalization in patients with COPD. STUDY DESIGN: and methods: Serum IgG levels were measured on baseline samples from four COPD cohorts (n=2,259): Azithromycin for Prevention of AECOPD (MACRO, n=976); Simvastatin in the Prevention of AECOPD (STATCOPE, n=653), Long-Term Oxygen Treatment Trial (LOTT, n=354), and COPD Activity: Serotonin Transporter, Cytokines and Depression (CASCADE, n=276). IgG levels were determined by immunonephelometry (MACRO; STATCOPE) or mass spectrometry (LOTT; CASCADE). The effect of hypogammaglobulinemia on COPD hospitalization risk was evaluated using cumulative incidence functions for this outcome and deaths (competing risk). Fine-Gray models were performed...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research