Acid Suppressants Increase Risk of Colonization with Multidrug-Resistant Microorganisms

According to this study: Use of acid suppressants is associated with a 75% increase in the risk of intestinal tract colonization with multidrug-resistant microorganisms in both the community and health care settings.More prudent use of acid suppressants may help to reduce the risks of colonization with multidrug-resistant microorganisms.
Source: AJN - Category: Nursing Tags: Journal Watch Source Type: research

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Publication date: September 2020Source: Journal of Global Antimicrobial Resistance, Volume 22Author(s): E.A. Rodríguez, L.M. Garzón, I.D. Gómez, J. Natalia Jiménez
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 3 July 2020Source: Saudi Pharmaceutical JournalAuthor(s): Thamer A Almangour, Basel Alenazi, Leen Ghonem, Abdullah A Alhifany, Bassam A Aldakheel, Alya Alruwaili
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
We report a case of acquired fluoroquinolone (FQ) resistance under short-course multidrug-resistant tuberculosis (MDR-TB) treatment. The patient was managed at Kabutare hospital, one of the two specialized MDR-TB clinics in Rwanda. A low dose of moxifloxacin was used in the first three critical months. Acquired resistance was identified at the ninth month of treatment, 3 months after stopping kanamycin in a strain initially susceptible only to FQs, kanamycin, and clofazimine. Fluoroquinolone resistance was detected in the same month by deep sequencing as routinely used second-line probe assay and phenotypic drug susceptibi...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Conclusions: Results showed a high level of oxacillinases producing A. baumannii circulating in our study setting, highlighting the need for local molecular surveillance to inform appropriate management and prevention strategies. PMID: 32612659 [PubMed]
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
Abstract In medical care, qualified physicians, nurses, and pharmacists have come to be recognized as a team integral to a patient's success, and this team approach to medical care has become popular. In the infectious disease field, more hospitals are practicing antimicrobial stewardship as a team, in addition to the conventional infection control team (ICT). As a result, infectious disease chemotherapy pharmacists are in demand. However, this specific qualification is hard to acquire for pharmacists working in a primary care pharmacy. The problem of multidrug-resistant bacteria is of vital interest today. The Na...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Publication date: Available online 2 July 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): João Pedro Rueda Furlan, Irys Hany Lima Gonzalez, Patrícia Locosque Ramos, Eliana Guedes Stehling
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
M. Jaspard et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
PSMA based radioligand is a new investigational drug for treatment of metastatic multidrug-resistant and castration-resistant prostate cancer. Prognostic factors point to above and below average overall survival (OS) after the treatment.Kessel et al. [Theranostics 2019;9:4841-8] reported for the first time that two sites of visceral metastases, lungs and liver, differed in impact on OS after treatment with 177Lu PSMA 617. Treatment with established drugs showed the same trend. The difference in OS between the sites is independent of the type of treatment and can reflect changes in tumor biology during the progression of me...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Editorial Source Type: research
Conclusion: These findings suggest that SiO2-PCe6-IL could rapidly increase the concentration of photosensitizer in biofilm and it is an effective therapy for combating biofilm infection.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors in diseased regions to increase the specificity of drug delivery. Currently, numerous nanocarriers have been engineered with physicochemical changes in responding to external stimuli, such as ultrasound, thermal, light and magnetic field, as well as internal stimuli, including pH, redox potential, hypoxia and enzyme, etc. Nanocarriers could respond to stimuli in tumor microenvironments or inside cancer cells for on-demanded drug delivery and accumulation, contr...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
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