Diagnostic 2-gene classifier in early-stage mycosis fungoides: A retrospective multicenter study

Although Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL), it still poses a major diagnostic challenge due to clinical and histological similarities to benign inflammatory dermatosis (BID) resulting in prolonged diagnostic workup (Scarisbrick et al. 2019). Algorithms based on clinical, morphological, immunophenotypical and molecular parameters have added to diagnostic accuracy in early stage disease (Pimpinelli et al. 2005). I addition, TOX, PDCD1, CADM1, BLK and genes related to the TNF signaling pathway have been reported as potential diagnostic markers (Litvinov et al.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research