Molecules, Vol. 25, Pages 2422: Phytochemical Analysis, Network Pharmacology and in Silico Investigations on Anacamptis pyramidalis Tuber Extracts
Molecules, Vol. 25, Pages 2422: Phytochemical Analysis, Network Pharmacology and in Silico Investigations on Anacamptis pyramidalis Tuber Extracts
Molecules doi: 10.3390/molecules25102422
Authors:
Mohamad Fawzi Mahomoodally
Marie Carene Nancy Picot-Allain
Gokhan Zengin
Eulogio J. Llorent-Martínez
Hassan H. Abdullah
Gunes Ak
Ismail Senkardes
Annalisa Chiavaroli
Luigi Menghini
Lucia Recinella
Luigi Brunetti
Sheila Leone
Giustino Orlando
Claudio Ferrante
Anacamptis pyramidalis (L.) Rich. forms part of the Orchidaceae family that is highlyvalued for its horticultural as well as therapeutic benefits. The present study set out to investigatethe inhibitory activity of A. pyramidalis tubers against key biological targets for the management oftype 2 diabetes, Alzheimer disease, and skin hyperpigmentation. In addition, the antioxidantpotential of the extracts was also assessed using multiple methods. The detailed phytochemicalprofiles of the extracts were determined using high‐performance liquid chromatography. Based onqualitative phytochemical fingerprint, a network pharmacology analysis was conducted as well.Parishin was identified from the water extract only, whereas gastrodin and caffeic acid derivativeswere present in the methanol extract. The methanol extract exhibited high inhibitory activityagainst tyrosinase (69.69 mg kojic acid equivalent/g extract), α‐amylase (15.76 mg acarboseequivalent/g extract), and α‐g...
Source: Molecules - Category: Chemistry Authors: Mohamad Fawzi Mahomoodally Marie Carene Nancy Picot-Allain Gokhan Zengin Eulogio J. Llorent-Mart ínez Hassan H. Abdullah Gunes Ak Ismail Senkardes Annalisa Chiavaroli Luigi Menghini Lucia Recinella Luigi Brunetti Sheila Leone Giustino Orlando Claudio Fer Tags: Article Source Type: research
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