Molecules, Vol. 25, Pages 2422: Phytochemical Analysis, Network Pharmacology and in Silico Investigations on Anacamptis pyramidalis Tuber Extracts

Molecules, Vol. 25, Pages 2422: Phytochemical Analysis, Network Pharmacology and in Silico Investigations on Anacamptis pyramidalis Tuber Extracts Molecules doi: 10.3390/molecules25102422 Authors: Mohamad Fawzi Mahomoodally Marie Carene Nancy Picot-Allain Gokhan Zengin Eulogio J. Llorent-Martínez Hassan H. Abdullah Gunes Ak Ismail Senkardes Annalisa Chiavaroli Luigi Menghini Lucia Recinella Luigi Brunetti Sheila Leone Giustino Orlando Claudio Ferrante Anacamptis pyramidalis (L.) Rich. forms part of the Orchidaceae family that is highlyvalued for its horticultural as well as therapeutic benefits. The present study set out to investigatethe inhibitory activity of A. pyramidalis tubers against key biological targets for the management oftype 2 diabetes, Alzheimer disease, and skin hyperpigmentation. In addition, the antioxidantpotential of the extracts was also assessed using multiple methods. The detailed phytochemicalprofiles of the extracts were determined using high‐performance liquid chromatography. Based onqualitative phytochemical fingerprint, a network pharmacology analysis was conducted as well.Parishin was identified from the water extract only, whereas gastrodin and caffeic acid derivativeswere present in the methanol extract. The methanol extract exhibited high inhibitory activityagainst tyrosinase (69.69 mg kojic acid equivalent/g extract), α‐amylase (15.76 mg acarboseequivalent/g extract), and α‐g...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research