S100A9 Links Inflammation and Repair in Myocardial Infarction.

Conclusions: We show that S100A9 plays an important role in both the inflammatory and the reparatory immune responses to MI. Long-term S100A9 blockade negatively impacts cardiac recovery and counterbalances the beneficial effects of short-term therapy. These results define a therapeutic window targeting the inflammatory phase for optimal effects of S100A9 blockade as potential immunomodulatory treatment in acute MI.
PMID: 32434457 [PubMed - as supplied by publisher]

Source: Circulation Research - May 20, 2020 Category: Cardiology Authors: Marinković G, Koenis D, de Camp L, Jablonowski R, Graber N, de Waard V, de Vries CJ, Goncalves I, Nilsson J, Jovinge S, Schiopu A Tags: Circ Res Source Type: research