Trends in reported antibiotic use among children under 5 years of age with fever, diarrhoea, or cough with fast or difficult breathing across low-income and middle-income countries in 2005–17: a systematic analysis of 132 national surveys from 73 countries

Publication date: June 2020Source: The Lancet Global Health, Volume 8, Issue 6Author(s): Gbemisola Allwell-Brown, Laith Hussain-Alkhateeb, Freddy Eric Kitutu, Susanne Strömdahl, Andreas Mårtensson, Emily White Johansson
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research

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CORONAVIRUS symptoms have been shown to manifest themselves in a number of ways, from a persistent cough to aches and pains and diarrhoea. With hay fever season also in full swing, are itchy eyes a sign of a pollen allergy or COVID-19? Dr Hilary Jones has issued his advice.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CORONAVIRUS symptoms include a high fever, a new cough, and loss of smell and taste. But you could also be at risk of COVID-19 infection if you notice a subtle change to your poo or toilet routine. Is diarrhoea a sign of coronavirus?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Studies have examined some of the more unusual signs of Covid-19Coronavirus – latest updatesSee all our coronavirus coverageThe World Health Organization lists the most common symptoms of Covid-19 as fever, tiredness and a dry cough. Others include a runny nose, sore throat, nasal congestion, pain, diarrhoea and the loss of sense of taste and/or smell. But there are also other more unusual symptoms that patients have presented.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World Health Organization Science Infectious diseases Source Type: news
CONCLUSIONS: For this current update, five new studies from the 2020 search contributed to existing findings but made little impact on outcomes described in earlier versions of this review. PDE₄ inhibitors offered a small benefit over placebo in improving lung function and reducing the likelihood of exacerbations in people with COPD; however, they had little impact on quality of life or on symptoms. Gastrointestinal adverse effects and weight loss were common, and the likelihood of psychiatric symptoms was higher, with roflumilast 500 µg. The findings of this review provide cautious support for the use of PDE₄ in...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Basel, 3 March 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation (BTD) to Esbriet ® (pirfenidone) for adults with unclassifiable interstitial lung disease (uILD). The designation was granted based on data from a Phase II trial, which studied the efficacy and safety of Esbriet in uILD[1]. The study represented the first randomised controlled trial to exclusively enroll patients with progressive fibrosing uILD.“Today’s milestone for Esbriet builds on our continued commitment to improving the standard of care ...
Source: Roche Investor Update - Category: Pharmaceuticals Source Type: news
ConclusionThese data suggest the antihyperglycaemic activity of HRS is mediated by inhibiting carbohydrate digestion and absorption, while significantly enhancing insulin secretion in a dose dependent manner. This suggests that HRS has potential as a novel antidiabetic therapy or a dietary supplement for the treatment of type 2 diabetes.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Basel, 06 February 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today presented 1-year data from the pivotal Part 2 of SUNFISH, a global placebo-controlled study evaluating risdiplam in people aged 2-25 years with Type 2 or 3 spinal muscular atrophy (SMA). The study showed that change from baseline in the primary endpoint of the Motor Function Measure scale (MFM-32)1 was significantly greater in people treated with risdiplam, compared to placebo (1.55 point mean difference; p=0.0156). The Revised Upper Limb Module (RULM),2 a key secondary endpoint, also showed an improvement (1.59 point difference; p=0.0028). Safety for risdi...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 30 January 2020Source: The LancetAuthor(s): Nanshan Chen, Min Zhou, Xuan Dong, Jieming Qu, Fengyun Gong, Yang Han, Yang Qiu, Jingli Wang, Ying Liu, Yuan Wei, Jia'an Xia, Ting Yu, Xinxin Zhang, Li ZhangSummaryBackgroundIn December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia.MethodsIn this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were con...
Source: The Lancet - Category: General Medicine Source Type: research
We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients.MethodsAll patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their ...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 7 January 2020Source: Journal of EthnopharmacologyAuthor(s): Diana Giles-Rivas, Samuel Estrada-Soto, A. Berenice Aguilar-Guadarrama, Julio Almanza-Pérez, Sara García-Jiménez, Blanca Colín-Lozano, Gabriel Navarrete-Vázquez, Rafael Villalobos-MolinaAbstractEthnopharmacological importance Cordia morelosanaStandley (Boraginaceae) is commonly used in folk medicine for the treatment of diarrhoea, kidney inflammation, diabetes, lung pain, bronchitis, asthma, hoarseness, cough and fever.AimCurrent work was conducted to develop a bio-guided isolation of antidiabe...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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