CDC Estimates That 35% Of People With Coronavirus Don ’ t Have Symptoms
(CNN) — In new guidance for mathematical modelers and public health officials, the US Centers for Disease Control and Prevention is estimating that about a third of coronavirus infections are asymptomatic. The CDC also says its “best estimate” is that 0.4% of people who show symptoms and have Covid-19 will die, and the agency estimates that 40% of coronavirus transmission is occurring before people feel sick. The agency cautions that those numbers are subject to change as more is learned about Covid-19, and it warns that the information is intended for planning purposes. Still, the agency says its estimates are based on real data collected by the agency before April 29. The numbers are part of five planning scenarios that “are being used by mathematical modelers throughout the federal government,” according to the CDC. Four of those scenarios represent “the lower and upper bounds of disease severity and viral transmissibility.” The fifth scenario is the CDC’s “current best estimate about viral transmission and disease severity in the United States.” In that scenario, the agency described its estimate that 0.4% of people who feel sick with Covid-19 will die. For people age 65 and older, the CDC puts that number at 1.3%. For people 49 and under, the agency estimated that 0.05% of symptomatic people will die. Expert pushes back Under the most severe of the five scenarios outlined — not the agency’s “be...
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TACB Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The solution of the SARS-CoV-2 Mpro structure allowed the investigation of potential inhibitors. This work aims to provide first evidences of the applicability of commercially approved drugs to treat coronavirus disease-19 (COVID-19). We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Our results evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structu...
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