FDA OKs Apomorphine Sublingual Film for'Off' Episodes in PD FDA OKs Apomorphine Sublingual Film for'Off' Episodes in PD

The FDA has approved apomorphine hydrochloride (Kynmobi) sublingual film as the first treatment of its kind for'off'episodes in patients with Parkinson's disease.FDA Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Alert Source Type: news

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Authors: Melchionda D, Varvara G, Perfetto D, Mascolo B, Avolio C Abstract Parkinson's disease (PD), which is not only a motor disease, is one of the most frequent neurodegenerative diseases and affects 1.5-2% of people worldwide. The role of its non motor-symptoms is of first importance on quality of life. Speech impairment is considered a part of motor impairment and is widespread in PD where most frequent speech impairment is Hypokinetic dysarthria, a disorder characterized by reduced articulation movements and phonetic monotony. Many PD patients show difficulty in accessing the lexicon related to cognitive impa...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Mitochondrial dysfunction and neurodegeneration have been directly correlated in many neurodegenerative disorders. Parkinson’s disease (PD) in particular has been extensively studied in this context because of its well-characterized association with mitophagy, a selective type of autophagy that degrades mitochondria. Mitophagy is triggered by ubiquitin modification of proteins residing on the surface of mitochondria. Therefore, mitophagy is subject to suppression by deubiquitination. In recent years, many deubiquitinase enzymes (DUBs) emerged as therapeutic targets to compensate hindered mitophagy in PD. It is reason...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In conclusion, our study demonstrated that crocin protected the DA projection neurons in the VTA through activating mTOR, which subsequentl y improved the neural synaptic plasticity of mPFC, and ameliorated depression-like behavior in PD mice.
Source: Molecular Neurobiology - Category: Neurology Source Type: research
ConclusionDespite the lack of statistical significance, when assessing the efficacy and safety outcomes for each drug in the evidence network, donepezil appeared to have a more favourable overall benefit/risk profile for patients with DLB. Further comparative trials are required to improve understanding of the true difference between existing and potential future treatment options.
Source: Neurology and Therapy - Category: Neurology Source Type: research
Authors: Lidstone SC, Bayley M, Lang AE Abstract INTRODUCTION: Parkinson's Disease (PD) is a chronic and slowly progressive neurodegenerative disease. Team-based care is required to address and manage the diverse array of motor and non-motor symptoms in PD and related conditions. As the evidence base for the efficacy of non-pharmacological treatment of PD is expanding, many different centers are implementing interdisciplinary models of care with allied health professionals trained in PD. AREAS COVERED: In this review, the authors outline these various models and review the evidence for multidisciplinary approaches ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
PARKINSON'S disease symptoms develop slowly over a long period of time, and could be caused by nerve damage in the brain. One of the more common warning signs of the neurodegenerative brain condition includes a change to the number of times you pass urine each day. Are you at risk of Parkinson's disease?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This week I’m in conversation with Mohanalakshmi Rajakumar. I was fortunate, back in 2012 to come across Mohana’s work and her book ‘Love comes later’. She very kindly graced my Thursday Throng in an interview and since then has gone on to win several awards for her work, including Best Indie Book Award for Romance in 2013. When we talked she explained how she felt about her challenging relationship with writing and gives a fantastic insight into the inner world of the writer. One piece of advice she gave was that a would-be author needs to be very clear about why they are writing in the first place...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Healthy Happy Writer author interview Source Type: news
Conclusions: HWE deviation of particular variants in relation to global populational HWE, could be, at least in part, associated with the differential susceptibility of specific populations and ethnicities to neurodegenerative diseases. Our data might contribute to the epidemiology and diagnostic/prognostic methods for neurodegenerative diseases.RESUMO Introdu ção: Mitocôndrias defeituosas ou danificadas resultam em alterações do metabolismo energético, equilíbrio redox e dinâmica celular e são, portanto, identificadas como o ponto central da patogênese em ...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
We examined the factors that affect levodopa PK in patients with Parkinson's disease (PD) and quantified the intensity of their respective effects.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
This article reports the effect of SCS following 3-years of SCS in our pilot study ’s cohort of PD patients [2].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
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