Large study finds drug Trump touted for Covid-19 is linked to greater risk of death and heart arrhythmia
Seriously ill Covid-19 patients who were treated with hydroxychloroquine or chloroquine were more likely to die or develop dangerous irregular heart rhythms, according to a large observational study published Friday in the medical journal The Lancet.
CONCLUSIONS: Further studies are required in order to establish the complicated association between SARS-CoV-2 infection and its effects on the cardiovascular system. Our knowledge regarding diagnostic approaches, therapeutic management and preventive measures is constantly enriched throughout an abundance of ongoing research in the respective fields. PMID: 32472990 [PubMed - as supplied by publisher]
Conclusion: This systematic review is aimed at summarizing all COVID-19 cases with a cardiac involvement published in paediatric age and trying to explain the underlying mechanisms responsible for COVID-19-related myocardial damage.What is Known:• Coronaviruses proved to be able to jump from animals to humans.• The outbreak of COVID-19 started from China (Dec 2019) and became pandemic.What is New:• Even in childhood, COVID-19 is not without the risk of cardiac involvement.• Myocarditis, heart failure, and arrhythmias are among the possible manifestations.
In this number of the International Journal of CardIology, a brief report by A. Cipriani et al. shows that treatment of patients with Covid-19 pneumonia with hydroxychloroquine plus azythromycin is associated with prolongation of QT interval, but it does not seem to correlate with an increased probability of relevant cardiac events, including arrhythmias, at least in subjects without prior cardiac disease (except hypertension). Moreover, the analysis of standard EKG plus 24-h Holter monitoring does not show significant circadian variations of QT interval in these patients.
Early during the current COVID-19 pandemic, hydroxychloroquine (HCQ) received a significant amount of attention as a potential antiviral treatment, such that it became one of the most commonly prescribed medications for COVID-19 patients. However, not only the effectiveness of HCQ has remained questionable, and mainly based on pre-clinical, and a few small clinical studies, but also HCQ is known to be potentially arrhythmogenic, especially as a result of QT prolongation.
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelera...
Abstract More than 1.6 million Americans have been infected with SARS-CoV-2 and>10 times that number carry antibodies to it. High-risk patients presenting with progressing symptomatic disease have only hospitalization treatment with its high mortality. An outpatient treatment that prevents hospitalization is desperately needed. Two candidate medications have been widely discussed: remdesivir, and hydroxychloroquine+azithromycin. Remdesivir has shown mild effectiveness in hospitalized inpatients, but no trials have been registered in outpatients. Hydroxychloroquine+azithromycin has been widely misrepresented in ...
Bardy Diagnostics is expanding the home enrollment program for its cardiac patch monitor and won CE mark for a 14-day version of the device. The Seattle, WA-based company said it was exploring more telehealth opportunities with Carnation Ambulatory Monitor (CAM) patch because of the rapidly evolving COVID-19 public health emergency. Typically, the CAM patch is applied to a patient in the clinic setting. In a prepared statement Ken Nelson,Â chief commercial officer of Bardy Diagnostics said, âTo help address the evolving needs of physicians and patients in this public health emergency, facilitat...
Hydroxychloroquine, chloroquine with or without macrolides linked to in - hospital mortality, arrhythmia
In December 2019, the Chinese public health authorities made public several cases of acute respiratory syndrome in the city of Wuhan caused by the novel SARS-CoV2 virus1,2. In our hyperconnected world, the initial outbreak experienced unprecedented dissemination and has now become this century ’s worst pandemic, with more than 4 million people infected and almost 300,000 deaths so far3.
Hydroxychloroquine has been touted as a potential treatment for COVID-19, but new observational data show it is not only without benefit but it increases death and arrhythmias.Medscape Medical News