Italy's daily coronavirus death toll dips, new cases steady

Italy recorded 130 new deaths from the COVID-19 epidemic on Friday against 156 the day before, the Civil Protection Agency said, while the daily tally of new cases rose marginally to 652 from 642 on Thursday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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In this study, we screened nsp15 as the most important viral encoded protein involved in TBK1 and IRF3 reduction. Endoribonuclease (EndoU) activity has been well determined for coronavirus nsp15. Three residues (H226, H241, and K282) of PEDV nsp15 were identified as critical amino acids for PEDV EndoU but not D265, which was not well correlated with published results of other coronaviruses, such as severe acute respiratory syndrome virus (SARS-CoV). Moreover, PEDV nsp15 can directly degrade the RNA levels of TBK1 and IRF3 dependent on its EndoU activity to suppress IFN production and constrain the induction of IFN stimulat...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
n Zhu The coronavirus disease 2019 (COVID-19) epidemic has had a crucial influence on people’s lives and socio-economic development throughout China and across the globe since December 2019. An understanding of the spatiotemporal patterns and influencing factors of the COVID-19 epidemic on multiple scales could benefit the control of the outbreak. Therefore, we used spatial autocorrelation and Spearman’s rank correlation methods to investigate these two topics, respectively. The COVID-19 epidemic data reported publicly and relevant open data in Hubei province were analyzed. The results showed tha...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusion: The current prevention and control measures have effectively reduced the transmissibility of COVID-19; however, R 0t is still larger than the threshold 1. The results show that the government adopting the Wuhan lockdown strategy plays an important role in restricting the potential infected persons in Wuhan outflow from the epidemic area and avoiding a nationwide spread by quickly controlling the potential infection in Wuhan. Meanwhile, since Jan. 18, 2020, the people successively accessed COVID-19-related information via the Internet, which may help to effectively implement the government's prevention and contr...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: The T-cell epitope-based peptide vaccine was designed for COVID-19 using the envelope protein as an immunogenic target. Nevertheless, the proposed vaccine rapidly needs to be validated clinically in order to ensure its safety and immunogenic profile to help stop this epidemic before it leads to devastating global outbreaks. PMID: 32461973 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
The novel coronavirus (SARS-CoV-2) that arose in China in December 2019 resulted in an epidemic that quickly expanded with particular intensity in the United States and European countries, particularly Italy and Spain, devastating the foundations of our nations in one of the most significant public health threats of our time. Sadly, this disease has spread globally, and from March 12 on, the American Society for Reproductive Medicine and European Society of Human Reproduction and Embryology made similarly cautious recommendations on managing patients who were undergoing infertility therapy or desiring pregnancy, but withou...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Inklings Source Type: research
America ’s decades-long relationship with the organization has been instrumental in improving health around the world.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) World Health Organization Presidential Election of 2020 United States Politics and Government Epidemics Centers for Disease Control and Prevention League of Nations Trump, Donald J Henderson, Donald A Frieden, Tho Source Type: news
This study analyzes the real time data from March 1 to April 22, 2020 by adopting a sophisticated statistical modeling based on the state space model combined with the well-known susceptible-infected-recovered (SIR) model. The model estimation and forecasting are conducted using the Bayesian methodology. The present study provides the parameter estimates of the unknown parameters that critically determine the epidemic process derived from the SIR model and prediction of the future transition of the infectious proportion including the size and timing of the epidemic peak with the prediction intervals that naturally accounts...
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
We appreciate the feedback and thoughtful discussion offered by Dr Hai and colleagues. We are pleased our paper is generating meaningful conversations as we all move through this uncharted territory of ethical conundrums created by the COVID-19 pandemic. As Dr Hai and colleagues point out, we are certainly aware of the differences between the HIV/AIDS epidemic of the 1980s/1990s and the current COVID-19 pandemic. The COVID-19 pandemic exceeds what any of us have seen, and therefore requires learning from all similar healthcare crises in history.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
ConclusionThe above-mentioned drugs can be regarded as candidates to treat COVID-19 infections, but further study on the efficiency of these drugs is also necessary.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
The pathogen is proving a familiar adage: The dose makes the poison.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) Masks Hygiene and Cleanliness Bathrooms and Toilets Epidemics Viruses Beth Israel Deaconess Medical Center Centers for Disease Control and Prevention Princeton University Source Type: news
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