Prdm3 and Prdm16  cooperatively maintain hematopoiesis and clonogenic potential

The genesis of mature blood cells in the adult bone marrow originates with multipotent self-renewing hematopoietic stem cells (HSCs), which reside at the top of an orchestrated but heterogeneous hierarchy of successive lineage commitment steps leading to oligolineage progenitors [1]; this process results in the production of mature circulating erythrocytes, platelets, and immune defense cells that populate the peripheral blood and immune organs. The regulation of this process is under the control of both intrinsic and extrinsic factors that drive, direct, and fine-tune this process in response to the needs of the organism.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Regular Submission Source Type: research