Association Between Secondary Botulinum Toxin  A Treatment Failure in Cosmetic Indication and Anti-Complexing Protein Antibody Production

ConclusionsBoT/A-exposed patients may develop antibodies against core botulinum toxin and complexing proteins. Our study is the first to demonstrate that anti-complexing protein antibodies cause BTF. High levels of antibodies against complexing proteins can cause onaA unresponsiveness, although some patients were still incoA-responsive. Our developed ELISA to detect anti-complexing protein antibodies can determine whether onaA-tolerant patients respond to incoA without incoA frontalis testing.

Source: Dermatology and Therapy - May 21, 2020 Category: Dermatology Source Type: research