Functional Modulation of Sarcolemmal KATP Channels by Atrial Natriuretic Peptide-Elicited Intracellular Signaling in Adult Rabbit Ventricular Cardiomyocytes.

In conclusion, here we report that ANP positively modulates the activity of ventricular sarcKATP channels via an intracellular signaling mechanism consisting of NPR-A, PKG, ROS, ERK1/2, CaMKII and RyR2. This novel mechanism may regulate cardiac excitability and contribute to cytoprotection, in part, by opening myocardial KATP channels. PMID: 32432931 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32432931?dopt=Abstract

Source: Am J Physiol Cell Ph... - May 19, 2020 Category: Cytology Authors: Zhang DM, Lin YF Tags: Am J Physiol Cell Physiol Source Type: research