2019 Water and Electrolyte Homeostasis Section Trainee Award: "Influences of Environmental Factors During Preeclampsia".

2019 Water and Electrolyte Homeostasis Section Trainee Award: "Influences of Environmental Factors During Preeclampsia". Am J Physiol Regul Integr Comp Physiol. 2020 May 20;: Authors: Dasinger JH, Abais-Battad JM, Mattson DL Abstract Preeclampsia is a pregnancy-specific disorder that impacts 5-8% of pregnancies and has long-term cardiovascular and metabolic implications for both mother and fetus. The mechanisms are unclear; however, it is believed that preeclampsia is characterized by abnormal vascularization during placentation resulting in the manifestation of clinical signs such as hypertension, proteinuria and endothelial dysfunction. While there is no current cure to alleviate the clinical signs, an emerging area of interest in the field is the influence of environmental factors including diet on the risk of preeclampsia. Since preeclampsia has serious cardiovascular implications on both the mother and fetus and most anti-hypertensive medications are contraindicated in pregnancy, it is important to investigate other potential therapeutic options such as dietary manipulation. The emerging field of nutrigenomics links diet with the gene expression of known pathways such as oxidative stress and inflammation via microbiome-mediated metabolites and could serve as one potential avenue of therapeutic targets for preeclampsia. While the exact role of nutrition in the pathogenesis of preeclampsia is unknown, this review will focus on kno...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research