Tumor-targeted dose escalation for localized prostate cancer using MR-guided HDR brachytherapy (HDR) or integrated VMAT (IB-VMAT) boost: Dosimetry, toxicity and health related quality of life

Radiation treatment (RT) is an effective option for men with localized prostate cancer (PCa).[1] However, local recurrences (LR) remain common in patients treated with external beam radiotherapy (EBRT) alone.[2] Dose-escalated RT to the whole gland (WG) has demonstrated increased locoregional and biochemical control in localized PCa.[3-5] A meta-analysis concluded that each 1-Gray (Gy) increased in dose delivered reduces 1.8% the risk of biochemical failure.[6] Nevertheless, concerns have been raised with regards to increased toxicity and subsequently worsening the quality of life (QoL) of patients treated with dose escalation.

Source: Radiotherapy and Oncology - May 20, 2020 Category: Radiology Authors: Noelia Sanmamed, Jenny Lee, Alejandro Berlin, Tim Craig, Bernadeth Lao, Alexandra Rink, Andrew Bayley, Charles Catton, Aravindhan Sundaramurthy, WarrenFoltz, Andrew McPartlin, Sangeet Ghai, Mary Gospodarowicz, Padraig Warde, Cynthia M énard, Peter Chung Tags: Original Article Source Type: research