Assumption Checking Before Application of the Prespecified QT Linear Mixed Effect Model is Essential

AbstractIn the paper, titled Evaluation of QT Liability for PF ‐05251749 in the Presence of Potential Circadian Rhythm Modification1, the authors presented results from assessment of QT ‐liability based on (i) clinical data and (ii) simulations using models for a drug that affects QT circadian rhythm.
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: LETTER TO THE EDITOR Source Type: research