Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype

Autoimmune diseases comprise a spectrum of illnesses and are on the rise worldwide. Although anti-nuclear antibodies (ANA) are detected in many autoimmune diseases, up to 20% of healthy women are ANA+ and most will never develop clinical symptoms. Further, disease transition is higher among ANA+ African Americans compared to European Americans.

Source: Journal of Allergy and Clinical Immunology - May 20, 2020 Category: Allergy & Immunology Authors: Samantha Slight-Webb, Miles Smith, Aleksandra Bylinska, Susan Macwana, Carla Guthridge, Rufei Lu, Joan T. Merrill, Eliza Chakravarty, Cristina Arriens, Melissa E. Munroe, Holden T. Maecker, Paul J. Utz, Joel M. Guthridge, Judith A. James Source Type: research