Characterising ISWI chromatin remodeler in Trypanosoma cruzi.

CONCLUSIONS In addition to its participation in transcriptional silencing, as it was reported in T. brucei, the data generated here provide a framework that suggests a role for TcISWI chromatin remodeler in different nuclear processes in T. cruzi, including mRNA nuclear export control and chromatin compaction. Further work is necessary to clarify the TcISWI functional diversity that arises from this protein interaction study.
PMID: 32428081 [PubMed - in process]

Source: Memorias do Instituto Oswaldo Cruz - May 21, 2020 Category: Infectious Diseases Authors: Díaz-Olmos Y, Batista M, Ludwig A, Marchini FK Tags: Mem Inst Oswaldo Cruz Source Type: research