Insights into Transdermal Drug Delivery: Approaches for Redressal of a Burgeoning Issue of Osteoporosis.

Insights into Transdermal Drug Delivery: Approaches for Redressal of a Burgeoning Issue of Osteoporosis. Endocr Metab Immune Disord Drug Targets. 2020 May 19;: Authors: Zakir F, Kohli K, Ahmad FJ, Iqbal Z, Ahmad A Abstract Osteoporosis is a progressive bone disease which remains unnoticed until a fracture occurs. It is more predominant in older age population particularly females due to reduced estrogen levels and ultimately limited calcium absorption. The cost burden of treating osteoporotic fractures is too expensive therefore primary focus should be treatment at an early stage. Most of the marketed drugs are available as oral delivery dosage forms. The complications as well as patient non-compliance limit the use of oral therapy for prolonged drug delivery. Transdermal delivery systems seem to be a promising approach for the delivery of antiosteoporotic active moieties. One of the confronting barriers is the passage of drugs through the SC layers followed by penetration to deeper dermal layers. The review focuses on how anti-osteoporotic drugs can be molded through different approaches so that they can be explored for skin to systemic delivery. Insights on the various challenges in transdermal delivery and how novel delivery system can be used to overcome these have also been detailed. PMID: 32433014 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research