Antimicrobial Terpenoids as a Potential Substitute in Overcoming Antimicrobial Resistance.

Antimicrobial Terpenoids as a Potential Substitute in Overcoming Antimicrobial Resistance. Curr Drug Targets. 2020 May 19;: Authors: Sharma A, Biharee A, Kumar A, Jaitak V Abstract There was a golden era where everyone thought that microbes can no longer establish threat to humans but the time has come where microbes are proposing strong resistance against majority of antimicrobials. Over the years the inappropriate use and easy availability of antimicrobials has made antimicrobial resistance (AMR) to be emerged as the world's third leading cause of death. Microorganisms over the time span have acquired resistance through various mechanisms such as efflux pump, transfer through plasmids causing mutation, changing antimicrobial site of action or modifying the antimicrobial which will leads to become AMR as the main cause of death worldwide by 2030. In order to overcome the emerging resistance against majority of antimicrobials there is a need to uncover drugs from plants because they have proved to be effective antimicrobials due to presence of secondary metabolites such as terpenoids. Terpenoids abundant in nature are produced in response to microbial attack have huge potential against various microorganisms through diverse mechanisms such as membrane disruption, anti-quorum sensing, inhibition of protein synthesis and ATP. New approaches like combination therapy of terpenoids and antimicrobials have increased the potency of treatmen...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research