Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis.

Conclusions: We herein present a comprehensive single-cell landscape of the cardiac immune cells in different EAM phases. In addition, we elucidated the contribution of Hif1a to the inflammatory response through the regulation of immune cell activity, particularly of macrophage cluster 2 and Th17 cells. Moreover, a Hif1a inhibitor alleviated inflammatory cell infiltration of the EAM model and may serve as a potential therapeutic target in the clinic.
PMID: 32431172 [PubMed - as supplied by publisher]

Source: Circulation - May 19, 2020 Category: Cardiology Authors: Hua X, Hu G, Hu Q, Chang Y, Hu Y, Gao L, Chen X, Yang PC, Zhang Y, Li M, Song J Tags: Circulation Source Type: research