Topical Oxygen Therapy Shifts Microbiome Dynamics in DFUs Topical Oxygen Therapy Shifts Microbiome Dynamics in DFUs

Topical oxygen treatment may alter the wound microbiome in diabetic foot ulcers, which may contribute to healing.Wounds
Source: Medscape Today Headlines - Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

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Conclusion: PCMP demonstrated clinically meaningful benefits to patients with various types of cutaneous wounds. Clinical Trial registration number: NCT03286452. PMID: 32476449 [PubMed - as supplied by publisher]
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Tags: J Comp Eff Res Source Type: research
To define the outcomes of persons with diabetes and foot ulcers (DFUs) managed through a specific triage pathway during the COVID-19 crisis.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Conclusion: This systematic review and meta-analysis will provide a comprehensive summary and careful evaluation of rifampicin as an adjuvant treatment of DFO with a view to providing multiple options for clinical treatment of the disease. Registration number: is INPLASY202040084.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Publication date: September 2020Source: Materials Science and Engineering: C, Volume 114Author(s): Le-Ping Yan, Irene Mencía Castaño, Rukmani Sridharan, Domhnall Kelly, Mark Lemoine, Brenton L. Cavanagh, Nicholas J. Dunne, Helen O. McCarthy, Fergal J. O'Brien
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
(Image source: WHO) There are two key differences between the novel coronavirus that causes COVID-19 and 5G technology. One has spread across the globe, the other has barely rolled out in most countries and in some cases not at all. That hasn’t stopped conspiracy theorists from conflating the two however. Thanks to a combination of scam artists, the reach of social media, ignorant celebrities and influencers, and general public frustration and confusion, a strange theory has emerged in the months since the global COVID-19 pandemic started. Allegedly, 5G is the culprit behind the pandemic. Citing a lot of ...
Source: MDDI - Category: Medical Devices Tags: Design News Source Type: news
CONCLUSION: Healing without major amputation was achieved in 84% of surviving patients ≥75 years, despite extensive comorbidity and dependency. PMID: 32448021 [PubMed - as supplied by publisher]
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
We report significant reduction in the expression of lncRNA MALAT1 in the infected Diabetic foot ulcers subjects which is positively correlated with the expression of angiogenic factors Nrf2, HIF-1α and VEGF. Further, expression of pro-inflammatory markers TNF-α and IL-6 increased while, the expression of anti-inflammatory marker IL-10 decreased in infected DFU tissues. Involvement of lncRNA MALAT1 in angiogenesis in EA.hy926 cells is demonstrated by silencing the expression of Nrf2, HIF-1α, and VEGF through interference mediated by MALAT1. Similarly, its inflammatory role is demonstrated by silencing t...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research
This study addresses the in vitrobiologic effects of a clinically available dehydrated amniotic membrane allograft (DAMA). The broad mechanism of action results from DAMA's biologic composition that leads to stimulation of cell migration cell proliferation, and reduction of pro ‐inflammatory cytokines. Results show that DAMA possesses growth factors and cytokines such as EGF, FGF, PDGFs, VEGF, TGF‐β, IL‐8, and TIMPs 1 and 2. Furthermore, in vitro experiments demonstrate that DAMA stimulates cell proliferation, cell migration, secretion of collagen type I, and the re duction of pro‐inflammatory cytokines IL‐1...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: ORIGINAL RESEARCH REPORT Source Type: research
This study addresses the in vitro biologic effects of a clinically available dehydrated amniotic membrane allograft (DAMA). The broad mechanism of action results from DAMA's biologic composition that leads to stimulation of cell migration cell proliferation, and reduction of pro-inflammatory cytokines. Results show that DAMA possesses growth factors and cytokines such as EGF, FGF, PDGFs, VEGF, TGF-β, IL-8, and TIMPs 1 and 2. Furthermore, in vitro experiments demonstrate that DAMA stimulates cell proliferation, cell migration, secretion of collagen type I, and the reduction of pro-inflammatory cytokines IL-1β, IL-...
Source: Biomed Res - Category: Research Authors: Tags: J Biomed Mater Res B Appl Biomater Source Type: research
Condition:   Foot Ulcer, Diabetic Intervention:   Other: No intervention Sponsors:   Podimetrics, Inc.;   American Association of Diabetes Educators Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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