Preventive Effects of Gardenia jasminoides on Cerulein-Induced Chronic Pancreatitis.

Preventive Effects of Gardenia jasminoides on Cerulein-Induced Chronic Pancreatitis. Am J Chin Med. 2020 May 20;:1-17 Authors: Choi JW, Jeong JH, Jo IJ, Kim DG, Shin JY, Kim MJ, Choi BM, Shin YK, Song HJ, Bae GS, Park SJ Abstract Our previous report revealed that Gardenia jasminoides (GJ) has protective effects against acute pancreatitis. So, we examined whether aqueous extract of GJ has anti-inflammation and antifibrotic effects even against cerulein-induced chronic pancreatitis (CP). CP was induced in mice by an intraperitoneal injection of a stable cholecystokinin (CCK) analogue, cerulein, six times a day, four days per week for three weeks. GJ extract (0.1 or 1[Formula: see text]g/kg) or saline (control group) were intraperitoneally injected 1[Formula: see text]h before first cerulein injection. After three weeks of stimulation, the pancreas was harvested for the examination of several fibrotic parameters. In addition, pancreatic stellate cells (PSCs) were isolated using gradient methods to examine the antifibrogenic effects of GJ. In the cerulein-induced CP mice, the histological features of the pancreas showed severe tissue damage such as enlarged interstitial spaces, inflammatory cell infiltrate and glandular atrophy, and tissue fibrosis. However, treatment of GJ reduced the severity of CP such as pancreatic edema and inflammatory cell infiltration. Furthermore, treatment of GJ increased pancreatic acinar cell survival, and reduced pancreatic fibr...
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research

Related Links:

AbstractPurposeTo evaluate the pancreatic duct cutoff sign in detecting pancreatic adenocarcinoma using CT and MRI.MethodsA retrospective analysis of patients with a pancreatic duct (PD) cutoff sign on CT or MRI from 2000 to 2019 was performed. The primary outcome measured was the presence or absence of a malignant pancreatic tumor. Variables evaluated included imaging characteristics of patients with a malignant versus non-malignant cause of duct cutoff and included PD size and PD-to-parenchyma ratio, contour abnormality, abnormal enhancement, diffusion abnormality, and upstream parenchymal atrophy.ResultsSeventy-two pati...
Source: Abdominal Imaging - Category: Radiology Source Type: research
Conclusions: Radiation-free ERCP guided bedside biliary drainage is effective and safe for critically ill patients, and ENBD may be an optimal procedure due to a low mortality in these patients. PMID: 32626738 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 6 July 2020Source: Journal of Visceral SurgeryAuthor(s): P. Tortajada, J.-J. Tuech, L. Schwarz
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
Publication date: Available online 7 July 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Ivan Adamec, Željko Reiner, Ivan Pećin, Nediljko Šućur, Ana Godan Hauptman, Barbara Barun, Tereza Gabelić, Mario Habek
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
CONCLUSION: The average cure rate with anthelminthic treatment is over 95%. Unfortunately, most treated patients in endemic areas become re-infected within months. Health education, personal hygiene, improved sanitary conditions, proper disposal of human excreta, and discontinuing the use of human fecal matter as a fertilizer are effective long-term preventive measures. Targeting deworming treatment and mass anthelminthic treatment should be considered in regions where A. lumbricoides is prevalent. PMID: 32628606 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Melatonin inhibits the endoplasmic reticulum stress‑induced, C/EBP homologous protein‑mediated pathway in acute pancreatitis. Mol Med Rep. 2020 Jun 10;: Authors: Zhao Q, Zhang H, Wu J, Lv X, Jin X, Hu J Abstract Melatonin, which is mainly secreted by the pineal gland, appears to have anti‑inflammatory activities. Acute pancreatitis (AP) is characterized by inflammation and acinar cell death, and is associated with a high mortality rate. It has been reported that melatonin can alleviate cerulein (Cer) or Cer + lipopolysaccharide (LPS)‑induced inflammatory responses in AR42J rat pancreatic acinar...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ConclusionThis first ESTES snapshot audit, a purely descriptive collaborative study, gives rich ‘real world’ insights into local variability in surgical practice as compared to international guidelines, and how this may impact upon outcomes. These granular data will serve to improve overall patient care as well as being hypothesis generating and inform areas needing future prospective stud y.
Source: European Journal of Trauma and Emergency Surgery - Category: Emergency Medicine Source Type: research
Abstract Muscle wasting represents a constant pathological feature of common chronic gastrointestinal diseases, including liver cirrhosis (LC), inflammatory bowel diseases (IBD), chronic pancreatitis (CP) and pancreatic cancer (PC), and is associated with increased morbidity and mortality. Recent clinical and experimental studies point to the existence of a gut-skeletal muscle axis that is constituted by specific gut-derived mediators which activate pro- and anti-sarcopenic signalling pathways in skeletal muscle cells. A pathophysiological link between both organs is also provided by low-grade systemic inflammatio...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
The interesting research of Chu Patricia et al., confirms the important clinical impact of the duodenum (D) stump leakage after distal gastrectomy, also today followed by not negligible morbidity and mortality.1 –3 This carries interesting points of discussion concerning indications and surgical techniques in case of an ‘incompetent’ D stump, that is unsuitable to a safe closure, as shorter than half of its lumen, provided of fibrotic walls or deteriorated by a difficult dissection. These conditions, commonly found at surgery, can be pre-operatively suspected on the base of gastrointestinal Rx series or C...
Source: American Journal of Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Conclusions: The new temperature-controlled RFA probe can be used with acceptable safety for the treatment of residual intraductal lesions after endoscopic papillectomy. Further evaluation through future prospective studies is needed. PMID: 32616684 [PubMed - as supplied by publisher]
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
More News: China Health | Complementary Medicine | Pancreas | Pancreatitis