Toward a Cure for Follicular Lymphoma

In 1984, Horning and Rosenberg published a seminal paper describing the natural history of follicular lymphoma (then also referred to as nodular poorly differentiated lymphocytic lymphoma) emphasizing the incidence of spontaneous regressions and histological transformation over time, the lack of benefit of early therapeutic intervention, and the incurable nature of the disease with a median overall survival of 11 years. They concluded that “an increased understanding of the cause and regulation of these low-grade B-cell neoplasms and their potential manipulation by new therapeutic approaches offers exciting avenues for research and should be pursued.”1
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Tags: Preface Source Type: research