$5.75M grant to help researchers study role of obesity in development of pancreatic cancer

A team of researchers from theUCLA Jonsson Comprehensive Cancer Center and peer institutions has been awarded a $5.75 milliongrant from the National Cancer Institute to study the correlation between obesity, inflammation and pancreatic cancer. The scientists hope their findings may help people avoid getting this cancer.“We know that the biological mechanisms of obesity, such as inflammation, can lead to the development of pancreatic cancer,” said Dr. Guido Eibl, professor-in-residence in the department of surgery at the David Geffen School of Medicine at UCLA and a Jonsson Cancer Center researcher. “This st udy will help us better understand not only how those mechanisms influence the formation of pancreatic tumors but also how we can develop preventions that help people who are at a higher risk for this cancer.”The five-year study will be structured into three projects, with participating researchers from Cedars –Sinai Medical Center in Los Angeles and the University of California, San Diego, joining the team at UCLA. Each project’s leader is highly experienced in the study of pancreatic cancer.The first project, overseen by Eibl, will examine the inflammation of body fat and how this chronic condition can lead to pancreatic cancer. The second, led by Jonsson Cancer Center researcher Dr. Enrique Rozengurt, who holds the Hirschberg Memorial Chair in Pancreatic Cancer Research at UCLA, will focus on the use of medications, and their mec...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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essandro Cama Pancreatic cancer (PC) is a lethal malignancy with rising incidence and limited therapeutic options. Obesity is a well-established risk factor for PC development. Moreover, it negatively affects outcome in PC patients. Excessive fat accumulation in obese, over- and normal-weight individuals induces metabolic and inflammatory changes of adipose tissue microenvironment leading to a dysfunctional adipose “organ”. This may drive the association between abnormal fat accumulation and pancreatic cancer. In this review, we describe several molecular mechanisms that underpin this association at...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
ConclusionThese results suggest that RPI prior to PC diagnosis is associated with a higher risk of death. Future studies with larger sample sizes are needed to explore whether this association varies across tumor histology.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsThese findings suggest that self-reported driver ’s license data provide a reasonable approximation of BMI, but are less precise than interview- and questionnaire-based methods. Furthermore, the degree of bias is seemingly unaffected by measurement order and time lag, but appears to become more pronounced as BMI itself increases.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Nature Reviews Gastroenterology &Hepatology, Published online: 01 June 2020; doi:10.1038/s41575-020-0324-6Obesity is a known risk factor for pancreatic cancer. Now, a new study reports that obesity accelerates early pancreatic cancer development and growth in mice through local perturbations in the pancreatic microenvironment and implicates pancreatic islet-derived cholecystokinin as a driving factor.
Source: Nature Reviews Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Abstract Tyrosine kinase inhibitors (TKIs) used in cancer are also being investigated in diabetes. TKIs can improve blood glucose control in diabetic cancer patients, but the specific kinases that alter blood glucose or insulin are not clear. We sought to define the role of Receptor Interacting Serine/Threonine Kinase 2 (RIPK2) in mouse models of insulin resistance. We tested the TKI gefitinib, which inhibits RIPK2 activity, in WT, Nod1-/-, Nod2-/- and Ripk2-/- mice fed an obesogenic high fat diet. Gefitinib lowered blood glucose during a glucose tolerance test (GTT) in a NOD-RIPK2-independent manner in all obese ...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
Abstract The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause of cancer-related death in the United States. The relationship among obesity, T2DM and PC is complex. Due to increase in obesity, diabetes, alcohol consumption and sedentary lifestyle, the mortality due to PC is expected to rise significantly by year 2040. The underlying mechanisms by which diabetes and obesity contribute to pancreatic tumorigenesis are not well understood. Furthermore, me...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Abstract Many cancer cells share the property of carrying out markedly elevated rates of glycolysis to generate energy even in the presence of sufficient oxygen, and this is known as the Warburg effect. In recent years, there has been a resurgence of interest in the Warburg effect, as the field of oncology has amassed evidence that cellular metabolism may play a prominent role in many neoplasms. Largely in the past decade, another prominent and perhaps surprising factor has emerged in the cancer literature: the catecholamine molecules, epinephrine (adrenaline) and norepinephrine (noradrenaline), appear to play a r...
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research
This study reviewed the literature on obesity and pancreatobiliary disease in terms of epidemiology and mechanism. PMID: 32448855 [PubMed - in process]
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Tags: Korean J Gastroenterol Source Type: research
ConclusionUsing nationwide clinical practice data, we created a preoperative risk model for postgastrectomy PIIC for gastric cancer.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
(University of California - Los Angeles Health Sciences) A team of researchers from the UCLA Jonsson Comprehensive Cancer Center and peer institutions has been awarded a $5.75 million grant from the National Cancer Institute to study the correlation between obesity, inflammation and pancreatic cancer. The scientists hope their findings may help people avoid getting this cancer.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
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