Parkinson’s disease symptoms: The early warning sign on your face

PARKINSON'S disease is a progressive disease so the symptoms become more disruptive over time. One early warning sign to watch out for can be seen in your facial expression.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 22 May 2020Source: Trends in Cognitive SciencesAuthor(s): Carolyn Parkinson, Meng Du
Source: Trends in Cognitive Sciences - Category: Psychiatry & Psychology Source Type: research
Molecules, Vol. 25, Pages 2444: Anti-aggregation Effects of Phenolic Compounds on α-synuclein Molecules doi: 10.3390/molecules25102444 Authors: Kenjiro Ono Mayumi Tsuji Tritia R. Yamasaki Giulio M. Pasinetti The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson’s disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the onset and progression of clinical phenotypes. Thus, there is increasing interest in developing strategies that attenuate...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Publication date: 2020Source: International Review of Neurobiology, Volume 152Author(s): Daniel J. van Wamelen, Yi-Min Wan, K. Ray Chaudhuri, Peter Jenner
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
PARKINSON's disease is a neurological brain condition that worsens over time. Best spotted sooner rather than later, what's the early sign you need to look out for when you go to the loo?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSION: Acoustic analysis of voice, using an electronic system, allows the identification of changes in voice parameters for predicting the worsening of disease and for targeting specific intervention. Among the voice parameters, jitter and shimmer significantly increased in patients with PD. PMID: 32436206 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
AbstractParkinson ’s disease (PD) is a neurodegenerative disorder closely associated with oxidative stress. The biochemical and cellular alterations that occur after cell and mouse treatment with the parkinsonism-inducing neurotoxin MPP+/MPTP are remarkably similar to those observed in idiopathic PD. Previously, we showed that ferulic acid (FA) has antioxidant properties and the ability to activate nuclear factor E2 –related factor 2 (Nrf2). The present study tested the hypothesis that FA attenuates MPP+/MPTP-induced oxidative stress by regulating crosstalk between sirtuin 2 (SIRT2) and Nrf2 pathways. To test t...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
AbstractObjectiveTo evaluate systematically the efficacy of exergames for balance dysfunction in neurological conditions and to identify factors of exergaming protocols that may influence their effects.MethodsWe searched electronic databases for randomized clinical trials investigating the effect of commercial exergames versus alternative interventions on balance dysfunction as assessed by standard clinical scales in adults with acquired neurological disabilities. Standardized mean differences (Hedge ’sg) were calculated with random-effects models. Subgroup analyses and meta-regression were run to explore potential m...
Source: Journal of Neurology - Category: Neurology Source Type: research
ConclusionThese findings reinforce the hypothesis that there may be different mechanisms contributing to VH and VI in PD, suggesting that these two entities may also have a different prognosis rather than simply lying along a continuous spectrum.Registration numberClinicaltrials.gov number NCT01114321.
Source: Journal of Neurology - Category: Neurology Source Type: research
The FDA has approved apomorphine hydrochloride (Kynmobi) sublingual film as the first treatment of its kind for'off'episodes in patients with Parkinson's disease.FDA Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Alert Source Type: news
May looked out the window for the sixth time in as many minutes. Sighing heavily she turned back to the table, scanned its contents and took a sip from the now cold coffee beside her. ‘this is driving me mad’ she said to the empty room. Another quick check through the window to see if anything had changed showed that it was exactly the same as it always was. Picture perfect village green and gentle hills framing the cottages opposite. Not that it had always been like this. Just a few short months ago, the view was a bustle of buses, cars and many, many people all milling about, snapping cameras or heading to on...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Writing friday fiction Source Type: news
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