Prototype Vaccine Protects Monkeys From Coronavirus

A series of animal experiments may point the way to an effective human vaccine, scientists said.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Clinical Trials Coronavirus (2019-nCoV) Vaccination and Immunization Monkeys and Apes Antibodies Immune System Beth Israel Deaconess Medical Center Science (Journal) National Institutes of Health Boston (Mass) Source Type: news

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Having trouble viewing this email? View it as a Web page. NIDCR's Summer 2020 E-Newsletter In this issue: NIDCR News Funding Opportunities NIH/HHS News Funding Notices Science Advances Subscribe to NICDR News Grantee News   NIDCR News NIDCR Announces Availability of COVID-19 Research Funding On May 5, NIDCR issued two Notices of Special Interest highlighting the urgent need for research on coronavirus disease 2019. This research may be conducted either via the National Dental PBRN infrastruc...
Source: NIDCR Science News - Category: Dentistry Source Type: news
Modern medicine still depends on this animal ’s blood to test for bacteria in vaccines. And an alternative test requires further study.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Product Tests Drugs (Pharmaceuticals) Vaccination and Immunization Coronavirus (2019-nCoV) Bacteria Biotechnology and Bioengineering Eli Lilly and Company Food and Drug Administration Lonza AG Moderna Inc Cape Cod (Mass) Europe Uni Source Type: news
AbstractGroup A rotavirus (RVA) and bovine coronavirus (BCoV) are the two main viral enteropathogens associated with neonatal calf diarrhea. The aim of the present survey was to investigate the epidemiology and the role of RVA and BCoV in the presentation of dairy and beef calf diarrhea in Lerma Valley of Salta province, within the Northwest region of Argentina. Stool samples of calves with or without diarrhea younger than 2  months of age were collected from 19 dairy farms and 20 beef farms between the years 2014 and 2016. Stool samples were screened for RVA and BCoV detection by ELISA. Heminested multiplex RT-PCR wa...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
Narendra Kumar Arora, Manoja Kumar DasIndian Journal of Public Health 2020 64(6):108-111 The whole globe is reeling under the COVID-19 pandemic now. With the scale and severity of infection, number of deaths and lack of any definite therapeutic armamentarium, the vaccine development has been accelerated at a never-before pace. A wide variety of vaccine technologies and platforms are being attempted. Out of the over 108 efforts, 100 are in preclinical and eight in Phase 1 or 2 trial stage. While the availability of newer technologies has facilitated development, there are several challenges on the way including limited und...
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
Discussions with the FDA are ongoing to define the required data set for filing Janssen’s Ebola vaccine regimen under the FDA’s Animal Rule licensure pathway. About Janssen’s Ebola Vaccine Regimen The Janssen investigational preventive Ebola vaccine regimen (Ad26.ZEBOV, MVA-BN-Filo) utilizes a viral vector strategy in which viruses – in this case adenovirus serotype 26 (Ad26) and Modified Vaccinia Virus Ankara (MVA) – are genetically modified so that they cannot replicate in human cells. In addition, these vectors are modified to safely carry the genetic code of an Ebola virus protein in order...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
CONCLUSIONS: This new disease is pushing the scientific community to develop swiftly a safe and effective vaccine. Notwithstanding the limitations of our analysis, given by the absence of available results, we try to provide a comprehensive view of the ongoing clinical trials in humans. Our analysis reveals a worldwide effort of both scientists and enterprises to achieve one of the most challenging goals of our century. PMID: 32456404 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Small animal models (mice, ferrets, hamsters) are essential for understanding how SARS-CoV-2 causes disease and for pre-clinical evaluation of vaccines and antiviral therapeutics. One promising model has been developed by modifying SARS-CoV-2 so that it binds to murine ACE2. Laboratory mice cannot be infected with SARS-CoV-2 because the viral spike glycoprotein (illustrated) does not bind […]
Source: virology blog - Category: Virology Authors: Tags: Uncategorized ACE2 antiviral coronavirus COVID-19 mouse model SARS-CoV-2 spike glycoprotein vaccine virology viruses Source Type: blogs
In this study, we generated a mouse model expressing human ACE2 (hACE2) by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young and aged hACE2 mice sustained high viral loads in lung, trachea, and brain upon intranasal infection. Although fatalities were not observed, interstitial pneumonia and elevated cytokines were seen in SARS-CoV-2 infected-aged hACE2 mice. Interestingly, intragastric inoculation of SARS-CoV-2 was seen to cause productive infection and lead to pulmonary pathological changes in hACE2 mice. Overall, this animal model described here provides a useful tool for studyi...
Source: Cell Host and Microbe - Category: Microbiology Authors: Tags: Cell Host Microbe Source Type: research
Advances in viral detection in bovine respiratory disease (BRD) have resulted from advances in viral sequencing of respiratory tract samples. New viruses detected include influenza D virus, bovine coronavirus, bovine rhinitis A, bovine rhinitis B virus, and others. Serosurveys demonstrate widespread presence of some of these viruses in North American cattle. These viruses sometimes cause disease after animal challenge, and some have been found in BRD cases more frequently than in healthy cattle. Continued work is needed to develop reagents for identification of new viruses, to confirm their pathogenicity, and to determine ...
Source: Veterinary Clinics of North America: Food Animal Practice - Category: Veterinary Research Authors: Source Type: research
Three studies published Wednesday suggest it should be possible to come up with a coronavirus vaccine — tests performed on animals have shown the right results to prove a vaccine could be possible.
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
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